二硼甲烷的化学选择性 Suzuki 偶联反应，用于方便地合成苄基硼酸酯。
Chemoselective Suzuki coupling of diborylmethane for facile synthesis of benzylboronates.
机构信息
Waseda Institute for Advanced Study, Shinjuku, Tokyo, 169-8050, Japan.
出版信息
Org Lett. 2011 Jul 1;13(13):3368-71. doi: 10.1021/ol201115k. Epub 2011 Jun 6.
PMID:21644527
Abstract
The chemoselective Pd-catalyzed Suzuki-Miyaura cross-coupling reaction using a diborylmethane is reported. The use of an equimolar amount of base with a diborylmethane realized chemoselective coupling for the synthesis of various benzylboronate derivatives. Sterically hindered aryl bromides can give products in moderate to excellent yields.
摘要
本文报道了一种钯催化的Suzuki-Miyaura 交叉偶联反应，使用二硼甲烷作为原料。反应中使用等摩尔量的碱，可以实现二硼甲烷的化学选择性偶联，从而合成各种苄基硼酸酯衍生物。空间位阻较大的芳基溴化物也可以以中等至优秀的收率得到产物。
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