Mäki T, Heikkonen E, Härkönen T, Kontula K, Härkönen M, Ylikahri R
Department of Clinical Chemistry, University of Helsinki, Finland.
Eur J Clin Invest. 1990 Jun;20(3):313-6. doi: 10.1111/j.1365-2362.1990.tb01862.x.
Plasma catecholamine levels, lymphocytic beta-adrenoceptor densities and lymphocytic cAMP production were studied in 10 male subjects attending a withdrawal clinic after prolonged alcohol abuse. On admission the mean beta-adrenoceptor density was 29 +/- 9 fmol mg-1 protein (about 60% of the mean level of healthy control subjects, P less than 0.002). The following day a significant elevation of the beta-adrenoceptor level up to 46 +/- 19 fmol mg-1 protein (P less than 0.05) took place. This was accompanied by a parallel activation of the beta-adrenoceptor-mediated cAMP production of the lymphocytes. No major changes in beta-adrenoceptor levels or cAMP production took place during the next 7 days. Plasma catecholamine levels were elevated at arrival and decreased steadily during the withdrawal period. In conclusion, chronic alcoholism is associated with a reduction of lymphocytic beta-adrenoceptor density and functioning, which is followed by a rapid reversal during abrupt ethanol withdrawal. Thus an accelerated responsiveness to catecholamines may occur during the first ethanol-free day of chronic alcoholics.
对10名长期酗酒后来到戒酒诊所的男性受试者的血浆儿茶酚胺水平、淋巴细胞β-肾上腺素能受体密度和淋巴细胞环磷酸腺苷（cAMP）生成情况进行了研究。入院时，平均β-肾上腺素能受体密度为29±9 fmol mg-1蛋白质（约为健康对照受试者平均水平的60%，P<0.002）。次日，β-肾上腺素能受体水平显著升高至46±19 fmol mg-1蛋白质（P<0.05）。与此同时，淋巴细胞中由β-肾上腺素能受体介导的cAMP生成也出现了相应的激活。在接下来的7天里，β-肾上腺素能受体水平或cAMP生成没有发生重大变化。血浆儿茶酚胺水平在入院时升高，在戒酒期间稳步下降。总之，慢性酒精中毒与淋巴细胞β-肾上腺素能受体密度及功能降低有关，而在突然戒酒期间会迅速逆转。因此，慢性酗酒者在戒酒的第一天可能会出现对儿茶酚胺反应性加速的情况。
