Patel P, O'Rahilly S, Buckle V, Nakamura Y, Turner R C, Wainscoat J S
Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford.
J Clin Pathol. 1990 May;43(5):377-8. doi: 10.1136/jcp.43.5.377.
DNA was extracted from tissue samples of three unrelated cases of insulinoma. Chromosome 11 allele loss was investigated using several chromosome 11 specific probes which detect restriction fragment length polymorphisms. In one case, which proved informative for many of the chromosome 11 markers, allele loss was shown on both 11p and 11q. This finding is of considerable interest as the allele loss closely corresponds to that recently reported in insulinomas occurring in the familial multiple endocrine neoplasia type 1 (MEN-1) syndrome.
从三例无亲缘关系的胰岛素瘤组织样本中提取了DNA。使用几种能检测限制性片段长度多态性的11号染色体特异性探针研究了11号染色体等位基因缺失情况。在一个对许多11号染色体标记具有信息价值的病例中，11p和11q均显示出等位基因缺失。这一发现相当有趣，因为该等位基因缺失与最近报道的家族性多发性内分泌腺瘤1型（MEN - 1）综合征中发生的胰岛素瘤的情况密切相符。
