Department of Colour Science, School of Chemistry, University of Leeds, UK.
Int J Pharm. 2011 Aug 30;415(1-2):95-101. doi: 10.1016/j.ijpharm.2011.05.054. Epub 2011 May 27.
Combinations of microcrystalline cellulose (MCC) and sodium carboxymethyl cellulose (Na-CMC) are commonly used as stabilising agents and suspending agents in pharmaceutical formulations. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. Also considered is the binding that occurs between the MCC and the Na-CMC. Avicel RC 591, a processed mixture of MCC and Na-CMC, is one of the more commonly used commercial suspending agents for aqueous compositions. Avicel RC 591 is used as an effective, blended stabilising agent. In this study, the contributions made by each of the components of Avicel RC 591 have been rationalised by monitoring the behaviour of the individual components in Avicel RC 591 suspensions or solutions. The hydrogels that are formed by Avicel RC 591 and by their laboratory formulated equivalent, which is spray dried (MCC+Na-CMC), have been characterised by confocal microscopy scanning electron microscopy and by dynamic light scattering. A 3D network structure that is formed by the MCC, in Avicel RC 591 is visualised. This network is supported by hydrogen bonding and by ionic interactions among and between the MCC, the Na-CMC and water. The strength of the network determines the physical properties of the hydrogel system, as seen in the rheological behaviour.
微晶纤维素（MCC）和羧甲基纤维素钠（Na-CMC）的组合通常用作药物制剂中的稳定剂和悬浮剂。本文基于对水凝胶形成、分解和恢复过程中发生的相互作用的研究。还考虑了 MCC 和 Na-CMC 之间的结合。Avicel RC 591 是 MCC 和 Na-CMC 的加工混合物，是水性组合物中较常用的商业悬浮剂之一。Avicel RC 591 用作有效的混合稳定剂。在这项研究中，通过监测 Avicel RC 591 悬浮液或溶液中各成分的行为，合理化了 Avicel RC 591 中每种成分的贡献。通过共焦扫描电子显微镜和动态光散射对由 Avicel RC 591 及其实验室配方等效物（喷雾干燥的 MCC+Na-CMC）形成的水凝胶进行了表征。可视化了在 Avicel RC 591 中由 MCC 形成的 3D 网络结构。该网络由 MCC、Na-CMC 和水之间的氢键和离子相互作用支撑。网络的强度决定了水凝胶系统的物理性质，如流变行为所示。
