胰岛素受体底物 1（IRS-1）基因 rs1801278 G>A 多态性与健康非糖尿病男性代谢综合征相关。受吸烟状况的调节。
The rs1801278 G>A polymorphism of IRS-1 is associated with metabolic syndrome in healthy nondiabetic men. Modulation by cigarette smoking status.
机构信息
Laboratory of Molecular Biology, Department of Genetics and Molecular Biology, School of Pharmacy and Biochemistry, University of Buenos Aires (UBA), Argentina.
出版信息
Diabetes Res Clin Pract. 2011 Sep;93(3):e95-7. doi: 10.1016/j.diabres.2011.05.018. Epub 2011 Jun 8.
AIMS
To explore associations between IRS-1 rs1801278 G>A polymorphism and metabolic syndrome (MS).
METHODS
rs1801278 G>A was genotyped in 610 healthy Argentinian men.
RESULTS
GA carriers had lower risk of MS (OR=0.52, P=0.045), particularly among smokers (OR=0.10, P=0.006).
CONCLUSIONS
rs1801278 GA carriers had lower risk of MS, especially among smokers.
目的
探讨 IRS-1 rs1801278 G>A 多态性与代谢综合征（MS）之间的关联。
方法
在 610 名健康的阿根廷男性中对 rs1801278 G>A 进行基因分型。
结果
GA 携带者患 MS 的风险较低（OR=0.52，P=0.045），尤其是吸烟者（OR=0.10，P=0.006）。
结论
rs1801278 GA 携带者患 MS 的风险较低，尤其是吸烟者。
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