Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Pediatrics. 2011 Jul;128(1):111-26. doi: 10.1542/peds.2010-3875. Epub 2011 Jun 6.
Bronchopulmonary dysplasia (BPD) frequently complicates preterm birth and leads to significant long-term morbidity. Unfortunately, few therapies are known to effectively prevent or treat BPD. Ongoing research has been focusing on potential therapies to limit inflammation in the preterm lung. In this review we highlight recent bench and clinical research aimed at understanding the role of inflammation in the pathogenesis of BPD. We also critically assess currently used therapies and promising developments in the field.
支气管肺发育不良（BPD）常并发于早产儿，并导致显著的长期发病率。不幸的是，目前已知的有效预防或治疗 BPD 的方法很少。正在进行的研究一直集中在潜在的治疗方法上，以限制早产儿肺部的炎症。在这篇综述中，我们重点介绍了最近旨在了解炎症在 BPD 发病机制中的作用的基础和临床研究。我们还批判性地评估了目前使用的治疗方法和该领域有希望的进展。
