Ozdemir Levent, Elonu Orhan Hakan, Gocmen Ayse Yesim
Department of Cardiology, Special Melikgazi Hospital, Kayseri, Turkey.
Int Heart J. 2011;52(3):143-5. doi: 10.1536/ihj.52.143.
Measurement of circulating cardiac biomarkers has enabled early diagnosis and risk assessment of acute coronary syndrome. Heart type fatty acid binding protein (H-FABP) is a relatively novel marker for the diagnosis of myocardial injury. The purpose of the present study was to compare H-FABP with Troponin I (cTnI) and creatine kinase myocardial band (CK-MB) in determining myocardial injury in patients with early stage of percutaneous coronary intervention (PCI). Blood was withdrawn one hour before and 3 hours after PCI from 40 patients to measure H-FABP, cTnI and CKMB. H-FABP was measured qualitatively. CK-MB and cTnI were measured by a sandwich enzyme-linked immunosorbent assay. Before PCI, H-FABP was found to be negative, while cTnI and CK-MB were found to be in normal ranges. Statistical analysis of measurements 3 hours after PCI revealed that H-FABP was significantly positive in 15 (37%) patients, while cTnI was elevated in 11 (27%) patients and CKMB was elevated in 8 (20%) patients. H-FABP is statistically more sensitive than cTnI and CK-MB at detecting myocardial injury after PCI.H-FABP can be used in early stages to detect myocardial injury caused by PCI. H-FABP is more sensitive than cTnI and CK-MB in determining myocardial injury due to PCI within 3 hours. H-FABP may help us stratify a patient's risk in early stages after PCI.
循环心脏生物标志物的检测有助于急性冠状动脉综合征的早期诊断和风险评估。心脏型脂肪酸结合蛋白（H-FABP）是一种相对较新的心肌损伤诊断标志物。本研究的目的是比较H-FABP与肌钙蛋白I（cTnI）和肌酸激酶同工酶（CK-MB）在经皮冠状动脉介入治疗（PCI）早期患者心肌损伤诊断中的作用。从40例患者中在PCI术前1小时和术后3小时采集血液，检测H-FABP、cTnI和CKMB。H-FABP进行定性检测。CK-MB和cTnI采用夹心酶联免疫吸附测定法检测。PCI术前，H-FABP呈阴性，而cTnI和CK-MB在正常范围内。PCI术后3小时检测结果的统计分析显示，15例（37%）患者H-FABP显著阳性，11例（27%）患者cTnI升高，8例（20%）患者CKMB升高。在检测PCI术后心肌损伤方面，H-FABP在统计学上比cTnI和CK-MB更敏感。H-FABP可用于早期检测PCI引起的心肌损伤。在3小时内，H-FABP在确定PCI所致心肌损伤方面比cTnI和CK-MB更敏感。H-FABP可能有助于我们在PCI术后早期对患者的风险进行分层。
