关闭信号转导通路中的差距。 - Suppr | 超能文献

Closing the GAP in a signal transduction pathway.

作者信息

Parsons J T

机构信息

Department of Microbiology, University of Virginia Health Sciences Center, Charlottesville 22908.

出版信息

Trends Genet. 1990 Jun;6(6):169-71. doi: 10.1016/0168-9525(90)90155-y.

DOI:10.1016/0168-9525(90)90155-y

Abstract

摘要

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1

Closing the GAP in a signal transduction pathway.关闭信号转导通路中的差距。

Trends Genet. 1990 Jun;6(6):169-71. doi: 10.1016/0168-9525(90)90155-y.

2

Regulation of ras p21 by GTPase activating proteins.GTP酶激活蛋白对ras p21的调控。

Cold Spring Harb Symp Quant Biol. 1991;56:237-41. doi: 10.1101/sqb.1991.056.01.029.

3

Binding of GAP to activated PDGF receptors.

Science. 1990 Mar 30;247(4950):1578-81. doi: 10.1126/science.2157284.

4

Coupling of ras p21 signalling and GTP hydrolysis by GTPase activating proteins.Ras p21信号传导与GTP酶激活蛋白介导的GTP水解的偶联

Philos Trans R Soc Lond B Biol Sci. 1992 Apr 29;336(1276):43-7; discussion 47-8. doi: 10.1098/rstb.1992.0042.

5

Signal transduction by receptor tyrosine kinases.

Cancer Treat Res. 1992;63:265-79. doi: 10.1007/978-1-4615-3088-6_13.

6

p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein.通过造血因子受体和c-kit激活p21ras需要酪氨酸激酶活性，但不需要p21ras GTP酶激活蛋白的酪氨酸磷酸化。

Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1587-91. doi: 10.1073/pnas.89.5.1587.

7

ras and GAP--who's controlling whom?Ras与GAP——究竟是谁在控制谁？

Cell. 1990 Jun 15;61(6):921-3. doi: 10.1016/0092-8674(90)90054-i.

8

PDGF induction of tyrosine phosphorylation of GTPase activating protein.血小板衍生生长因子诱导GTP酶激活蛋白的酪氨酸磷酸化。

Nature. 1989 Dec 7;342(6250):711-4. doi: 10.1038/342711a0.

9

PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex.

Cell. 1990 Apr 6;61(1):125-33. doi: 10.1016/0092-8674(90)90220-9.

10

Platelet-derived growth factor-induced p21ras-mediated signaling is independent of platelet-derived growth factor receptor interaction with GTPase-activating protein or phosphatidylinositol-3-kinase.血小板衍生生长因子诱导的p21ras介导的信号传导独立于血小板衍生生长因子受体与GTP酶激活蛋白或磷脂酰肌醇-3-激酶的相互作用。

Cell Growth Differ. 1994 Mar;5(3):341-7.

引用本文的文献

1

Suppression of src transformation by overexpression of full-length GTPase-activating protein (GAP) or of the GAP C terminus.通过全长GTP酶激活蛋白（GAP）或GAP C末端的过表达抑制src转化。

Mol Cell Biol. 1991 May;11(5):2819-25. doi: 10.1128/mcb.11.5.2819-2825.1991.

2

Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells.在表皮生长因子和血小板衍生生长因子受体刺激下以及在多瘤病毒中T抗原转化细胞中，一种120千道尔顿的pp60src底物发生酪氨酸磷酸化。

Mol Cell Biol. 1991 Feb;11(2):713-20. doi: 10.1128/mcb.11.2.713-720.1991.