一名接受卡氮芥（1,3-双（2-氯乙基）-1-亚硝基脲）治疗多形性胶质母细胞瘤的患者出现多处肺部病变。

Multiple pulmonary lesions in a patient treated with BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) for glioblastoma multiforme.

作者信息

Bellot P A, Valdiserri R O

出版信息

Cancer. 1979 Jan;43(1):46-50. doi: 10.1002/1097-0142(197901)43:1<46::aid-cncr2820430106>3.0.co;2-c.

DOI:10.1002/1097-0142(197901)43:1<46::aid-cncr2820430106>3.0.co;2-c

Abstract

A patient with a glioblastoma multiforme who was treated with BCNU, developed rapidly progressive pulmonary disease. The pulmonary changes were studied pathologically and included atypical alveolar cell hyperplasia, hyaline membranes, and interstitial fibrosis. These lesions contributed to the patient's demise and may be related to the administration of BCNU.

摘要

一名接受卡氮芥治疗的多形性胶质母细胞瘤患者出现了快速进展的肺部疾病。对肺部变化进行了病理研究，发现包括非典型肺泡细胞增生、透明膜和间质纤维化。这些病变导致了患者死亡，可能与卡氮芥的使用有关。