Department of Materials Science and Engineering, Yonsei University, 134 Shinchon-dong, Seoul 120-749, Korea.
Macromol Rapid Commun. 2011 Aug 17;32(16):1247-52. doi: 10.1002/marc.201100199. Epub 2011 Jun 3.
This study reports a continuous prepartion of spherical or hemispherical polymer particles simply utilizing the phase separation in polymer blend films during the coating process. We took an advantage of the strong phase separation between a water-soluble crystalline polymer as a matrix and hydrophobic polymers as minor components. We demonstrated the prepartion of water-soluble polystyrene (PS) particles, nitrilotriacetic acid (NTA)-functionalized PS particles for protein separation, and semiconducting poly(3-hexylthiophene) (P3HT) particles. The sizes of the particles could be controlled by adjusting the film thickness and weight fraction of the minor component polymers in the blend film. It provides a simple facile way to prepare polymer particles in a continous process.
本研究报告了一种连续制备球形或半球形聚合物粒子的方法，该方法简单地利用聚合物共混膜在涂层过程中的相分离。我们利用水溶性结晶聚合物作为基质与疏水性聚合物作为少量成分之间的强相分离优势。我们展示了水溶性聚苯乙烯（PS）粒子、用于蛋白质分离的氮川三乙酸（NTA）功能化 PS 粒子和半导体聚（3-己基噻吩）（P3HT）粒子的制备。通过调整共混膜中少量成分聚合物的膜厚度和重量分数，可以控制粒子的尺寸。它为在连续过程中制备聚合物粒子提供了一种简单易用的方法。
