Toda N, Okamura T
Department of Pharmacology, Shiga University of Medical Sciences, Ohtsu, Japan.
Biochem Biophys Res Commun. 1990 Jul 16;170(1):308-13. doi: 10.1016/0006-291x(90)91275-w.
Treatment with L-NG-monomethyl arginine (L-NMMA), an inhibitor of nitric oxide (NO) synthesis from L-arginine, suppressed the relaxant response of dog cerebral artery strips to transmural electrical stimulation and nicotine, as did oxyhemoglobin. The inhibition by L-NMMA was reversed or prevented by L-, but not D-, arginine. It is concluded that NO or an NO-related compound may play a crucial role in transmitting information from excited vasodilator nerves to cerebroarterial smooth muscle.
用L-NG-单甲基精氨酸（L-NMMA，一种从L-精氨酸合成一氧化氮（NO）的抑制剂）进行处理，抑制了犬脑动脉条对跨壁电刺激和尼古丁的舒张反应，氧合血红蛋白的作用也是如此。L-NMMA的抑制作用可被L-精氨酸逆转或预防，但不能被D-精氨酸逆转或预防。得出的结论是，NO或一种与NO相关的化合物可能在将信息从兴奋的血管舒张神经传递至脑动脉平滑肌中起关键作用。
