Kojori Fatemeh, Cronin Catherine M G, Salamon Elizabeth, Burym Craig, Sellers Elizabeth Ann Cameron
Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Manitoba, Canada.
J Pediatr Endocrinol Metab. 2011;24(3-4):203-4. doi: 10.1515/jpem.2011.123.
Maternal adrenal cortical carcinoma in pregnancy is rare. We report a case of an infant born to a mother with a history of adrenal cortical carcinoma. The pregnancy was complicated by fetal exposure to mitotane and dexamethasone. Despite the potential teratogenic exposures, there was no evidence of adrenal dysfunction in the infant. Growth and development at 12 months of age are normal and prognosis appears favorable. The long-term impact of fetal exposure to mitotane and glucocorticoid requires further investigation.
孕期母亲肾上腺皮质癌较为罕见。我们报告了一例母亲有肾上腺皮质癌病史的婴儿出生病例。该孕期因胎儿接触米托坦和地塞米松而变得复杂。尽管存在潜在的致畸暴露情况，但婴儿并无肾上腺功能障碍的证据。婴儿12个月时的生长发育正常，预后似乎良好。胎儿接触米托坦和糖皮质激素的长期影响需要进一步研究。
