[突触体因子对钠钾ATP酶作用的动力学分析]

[A kinetic analysis of the action of a synaptosomal factor on Na, K-ATPase].

作者信息

Kometiani Z P, Tsakadze L G

出版信息

Nauchnye Doki Vyss Shkoly Biol Nauki. 1990(3):36-42.

Abstract

A synaptosomal factor stimulated by neurotransmitters activates the Na, K-ATPase system effecting the phosphorylating intermediates moving the Na, K-ATPase system in the mode of simultaneous transport of Na+ and K+. This conclusion has been made during the analysis of kinetics of the effect of MgATP complex, free Mg2+ ions and ATP on Na, K-ATPase activity. Unlike the EGTA, the factor under study does not change the number of essential activators (ions of Na+ and K+) of the Na, K-ATPase system at the equimolar ATP and Mg2+ correlation.

摘要

一种由神经递质刺激产生的突触体因子激活钠钾ATP酶系统，影响磷酸化中间体，使钠钾ATP酶系统以同时转运Na⁺和K⁺的方式运转。这一结论是在分析MgATP复合物、游离Mg²⁺离子和ATP对钠钾ATP酶活性影响的动力学过程中得出的。与乙二醇双四乙酸（EGTA）不同，在所研究的因子存在下，当ATP和Mg²⁺等摩尔相关时，钠钾ATP酶系统的必需激活剂（Na⁺和K⁺离子）数量不会改变。