Levy M, Cernacek P
Department of Physiology, McGill University, Montréal, Qué., Canada.
Can J Physiol Pharmacol. 1990 Jun;68(6):663-6. doi: 10.1139/y90-099.
Previous studies have shown that when atrial natriuretic peptide (ANF) is given to anaesthetized dogs with hypovolemic acute pancreatitis, it will produce a diuresis and natriuresis but will not elevate the glomerular filtration rate (GFR). When the same dose of peptide is given to dogs equally hypovolemic (hemorrhage) but without pancreatitis, a brisk increment in GFR occurs. GFR will, however, rise in dogs with pancreatitis in response to other peptides, such as glucagon. In these studies we assessed cGMP excretion as a marker for ANF effect in both normal anaesthetized dogs and dogs with acute experimental pancreatitis. In each group, urinary output and sodium excretion increased significantly, but GFR rose only in the control group. Urinary excretion of cGMP rose equally and dramatically in both control and experimental animals. We conclude that GFR is prevented from rising in dogs with experimental pancreatitis following ANF, but this effect does not depend on depressed cGMP generation.
以往的研究表明，给患有低血容量性急性胰腺炎的麻醉犬注射心房利钠肽（ANF）时，会产生利尿和利钠作用，但不会提高肾小球滤过率（GFR）。给同等低血容量（出血）但无胰腺炎的犬注射相同剂量的该肽时，GFR会迅速升高。然而，患有胰腺炎的犬对其他肽类（如胰高血糖素）有反应时，GFR会升高。在这些研究中，我们评估了cGMP排泄情况，以此作为正常麻醉犬和急性实验性胰腺炎犬中ANF效应的标志物。在每组中，尿量和钠排泄量均显著增加，但仅对照组的GFR升高。对照组和实验组动物的cGMP尿排泄量均同等程度且显著升高。我们得出结论，实验性胰腺炎犬在注射ANF后GFR升高受阻，但这种效应并不依赖于cGMP生成的降低。
