Oesterling J E, Brendler C B, Burgers J K, Marshall F F, Epstein J I
Department of Urology, Johns Hopkins University School of Medicine, Baltimore.
Cancer. 1990 May 1;65(9):1928-36. doi: 10.1002/1097-0142(19900501)65:9<1928::aid-cncr2820650910>3.0.co;2-x.
Undifferentiated small cell carcinoma of the bladder is a rare tumor with pathologic features similar to those of oat cell carcinoma of the lung. This neuroendocrine neoplasm of the bladder has a highly malignant biological behavior; most patients present with either locally advanced or distant metastatic disease and die despite aggressive therapy. Here the histologic, immunocytochemical, and ultrastructural features of small cell carcinoma of the bladder are reviewed in detail. In addition, two patients with advanced small cell carcinoma of the bladder who were treated successfully with radical cystoprostatectomy and adjuvant methotrexate, vinblastine, doxorubicin, and cisplatin chemotherapy (M-VAC) are presented. Both men had regional lymph node involvement and are disease free at follow-up of 1 year and 2.5 years, respectively. This is the first report of combined surgical and M-VAC chemotherapy in the treatment of undifferentiated small cell carcinoma of the bladder.
膀胱未分化小细胞癌是一种罕见肿瘤，其病理特征与肺燕麦细胞癌相似。这种膀胱神经内分泌肿瘤具有高度恶性的生物学行为；大多数患者就诊时已处于局部晚期或发生远处转移，尽管接受了积极治疗仍会死亡。本文详细回顾了膀胱小细胞癌的组织学、免疫细胞化学及超微结构特征。此外，还介绍了两名晚期膀胱小细胞癌患者，他们接受了根治性膀胱前列腺切除术及甲氨蝶呤、长春碱、阿霉素和顺铂联合化疗（M-VAC）并获得成功治疗。两名男性患者均有区域淋巴结受累，分别在随访1年和2.5年时无疾病复发。这是关于联合手术及M-VAC化疗治疗膀胱未分化小细胞癌的首例报告。
