Bhattacherjee P, Paterson C A
KY Lions Eye Research Institute, University of Louisville 40292.
Exp Eye Res. 1990 Jul;51(1):93-6. doi: 10.1016/0014-4835(90)90175-t.
The effect of indomethacin and dexamethasone on the inflammatory response to intraocularly injected prostaglandin E2 (PGE2), leukotriene B4 (LTB4), and formyl-methionyl-leucyl phenylalanine (FMLP) has been examined in rabbits. PGE2, in nanogram quantities, dose-dependently increased intraocular pressure and protein concentration in the aqueous humor. These responses were not affected by an anti-inflammatory dose of dexamethasone, but indomethacin had a small insignificant inhibitory effect. LTB4 and FMLP caused substantial leukocyte accumulation in the anterior chamber and did not disrupt the blood-aqueous barrier. Neither indomethacin nor dexamethasone had any effect on the leukocyte response to LTB4 However, dexamethasone significantly reduced the FMLP-induced leukocyte response. These results suggest that PGE2 and LTB4 do not elicit a further release of AA metabolites and that their actions are direct. However, the chemofactic response of polymorphonuclear leukocytes to FMLP appears to be mediated by lipoxygenase products.
