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Ca modulates outward current through IK1 channels.

作者信息

Mazzanti M, DeFelice L J

机构信息

Department of Anatomy and Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322.

出版信息

J Membr Biol. 1990 Jun;116(1):41-5. doi: 10.1007/BF01871670.

DOI:10.1007/BF01871670
PMID:2165175
Abstract

Inward-rectifier channels in cardiac cells (IK1) stabilize the resting membrane potential near the K equilibrium potential. Here we investigate the role of IK1 in the regulation of action potentials and link this to the influx of Ca during beating. Inward Ca current alters the open-channel probability of outward IK1 current. Thus Ca ions depolarize cells not only by carrying an inward current but also by blocking an outward current.

摘要

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本文引用的文献

1
Single channel analysis of the inward rectifier K current in the rabbit ventricular cells.兔心室肌细胞内向整流钾电流的单通道分析
Jpn J Physiol. 1983;33(6):1039-56. doi: 10.2170/jjphysiol.33.1039.
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Voltage-dependent inactivation of inward-rectifying single-channel currents in the guinea-pig heart cell membrane.豚鼠心肌细胞膜内向整流单通道电流的电压依赖性失活
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Conductance properties of single inwardly rectifying potassium channels in ventricular cells from guinea-pig heart.
钙离子诱导的犬和人心室心肌内向整流钾电流（IK1）的增强。
Pflugers Arch. 2013 Nov;465(11):1621-35. doi: 10.1007/s00424-013-1309-x. Epub 2013 Jun 27.
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Human ether-à-go-go-related gene K+ channel gating probed with extracellular ca2+. Evidence for two distinct voltage sensors.用细胞外钙离子探测人去极化激活延迟整流钾离子通道相关基因钾通道门控。存在两种不同电压感受器的证据。
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beta-Adrenergic modulation of the inwardly rectifying potassium channel in isolated human ventricular myocytes. Alteration in channel response to beta-adrenergic stimulation in failing human hearts.离体人心室肌细胞内向整流钾通道的β-肾上腺素能调节。衰竭人心脏中通道对β-肾上腺素能刺激反应的改变。
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Molecular and biophysical view of the Ca channel: a hypothesis regarding oligomeric structure, channel clustering, and macroscopic current.钙通道的分子与生物物理视角：关于寡聚体结构、通道聚集及宏观电流的一种假说
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Voltage-dependent block by internal Ca2+ ions of inwardly rectifying K+ channels in guinea-pig ventricular cells.豚鼠心室肌细胞内向整流钾通道的内向钙离子电压依赖性阻滞作用
J Physiol. 1993 Oct;470:295-311. doi: 10.1113/jphysiol.1993.sp019859.
8
Modulation of K+ and Ca2+ channels by histamine H1-receptor stimulation in rabbit coronary artery cells.组胺H1受体刺激对兔冠状动脉细胞中钾离子和钙离子通道的调节作用
J Physiol. 1993 Aug;468:379-400. doi: 10.1113/jphysiol.1993.sp019777.
9
Dynamics of the inward rectifier K+ current during the action potential of guinea pig ventricular myocytes.豚鼠心室肌细胞动作电位期间内向整流钾电流的动力学
Biophys J. 1991 Dec;60(6):1534-9. doi: 10.1016/S0006-3495(91)82187-7.
10
Role of an inwardly rectifying potassium current in rabbit ventricular action potential.内向整流钾电流在兔心室动作电位中的作用。
J Physiol. 1992 Mar;448:709-27. doi: 10.1113/jphysiol.1992.sp019066.
豚鼠心室肌细胞中单个内向整流钾通道的电导特性
J Physiol. 1984 Feb;347:641-57. doi: 10.1113/jphysiol.1984.sp015088.
4
Regulation of spontaneous activity and growth of embryonic chick heart cells in tissue culture.组织培养中鸡胚心脏细胞自发活动和生长的调节
Dev Biol. 1967 Sep;16(3):216-49. doi: 10.1016/0012-1606(67)90025-5.
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K channel kinetics during the spontaneous heart beat in embryonic chick ventricle cells.胚胎期鸡心室细胞自发心跳过程中的钾通道动力学
Biophys J. 1988 Dec;54(6):1139-48. doi: 10.1016/S0006-3495(88)83048-0.
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Intracellular Ca modulates K-inward rectification in cardiac myocytes.
Pflugers Arch. 1989 Jan;413(3):322-4. doi: 10.1007/BF00583549.
7
Modulation of the delayed rectifier potassium current in frog cardiomyocytes by beta-adrenergic agonists and magnesium.β-肾上腺素能激动剂和镁对蛙心肌细胞延迟整流钾电流的调节作用
J Physiol. 1989 Aug;415:251-74. doi: 10.1113/jphysiol.1989.sp017721.
8
Open-state substructure of inwardly rectifying potassium channels revealed by magnesium block in guinea-pig heart cells.豚鼠心脏细胞中镁离子阻滞揭示内向整流钾通道的开放态亚结构
J Physiol. 1988 Mar;397:237-58. doi: 10.1113/jphysiol.1988.sp016998.
9
Surface charge near the cardiac inward-rectifier channel measured from single-channel conductance.通过单通道电导测量心脏内向整流通道附近的表面电荷。
J Membr Biol. 1988 Apr;102(1):1-10. doi: 10.1007/BF01875348.
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Effects of intracellular free magnesium on calcium current in isolated cardiac myocytes.细胞内游离镁对离体心肌细胞钙电流的影响。
Science. 1988 Feb 12;239(4841 Pt 1):778-80. doi: 10.1126/science.2448878.