Morgan A R, Severini A
Department of Biochemistry, University of Alberta, Edmonton, Canada.
J Theor Biol. 1990 May 22;144(2):195-202. doi: 10.1016/s0022-5193(05)80318-2.
Replication and recombination structures can be interconverted by branch-migration. Using this simple concept a novel mechanism is proposed for generating concatemers through an initial single-strand DNA invasion into a duplex. Only DNAs with terminal repeats can form concatemers, and Herpes Simplex Virus DNA replication is considered in detail. The model is more parsimonious than other models such as Watson's for concatemer formation.
复制和重组结构可通过分支迁移相互转换。基于这一简单概念，提出了一种新机制，即通过初始单链DNA侵入双链体来产生串联体。只有具有末端重复序列的DNA才能形成串联体，并对单纯疱疹病毒DNA复制进行了详细探讨。该模型比其他如沃森串联体形成模型更为简约。
