Pathology Unit of the General Hosptial of Mexico and Medicine School, National University of Mexico, Mexico.
Ann Diagn Pathol. 2011 Oct;15(5):312-7. doi: 10.1016/j.anndiagpath.2011.01.008. Epub 2011 Jun 8.
Malignant tumors of the uterine corpus are uncommon. They originate from the endometrial stroma, smooth muscle, blood vessels, or from a mixture of them. The objective of this article was to know the frequency and the clinical, morphologic, and immunophenotype characteristics of the endometrial stromal sarcoma (ESS). We reviewed the cases of ESS observed from 2002 to 2008 at the Pathology Unit of the General Hospital of Mexico. The following data were analyzed: age, clinical stage, degree of differentiation, and immunophenotype. We found 18 cases, and the average age of patients was 48.6 years; 66% were in clinical stages 1 and 2. Fifteen cases (83.3%) were classified as low-grade sarcomas and 3 (16.6%) as high-grade or undifferentiated sarcomas. We determined immunohistochemical markers in 17 cases; receptors to estrogens were positive in 5 (29.4%) and to progesterone in 9 (52.9%). CD10 was expressed in 10 (58.8%) and p53 in 11 cases (64.7%). Two cases were associated to primary tumors of the ovary (papillary cystadenocarcinoma). In conclusion, ESS was present at 0.6% in our institution; and most were low grade. Expression of markers, such as p53, CD10, and hormonal receptors, was positive.
子宫体恶性肿瘤并不常见。它们起源于子宫内膜基质、平滑肌、血管，或它们的混合物。本文的目的是了解子宫内膜间质肉瘤（ESS）的频率以及临床、形态和免疫表型特征。我们回顾了 2002 年至 2008 年在墨西哥总医院病理科观察到的 ESS 病例。分析了以下数据：年龄、临床分期、分化程度和免疫表型。我们发现了 18 例，患者的平均年龄为 48.6 岁；66%处于临床分期 1 和 2。15 例（83.3%）为低级别肉瘤，3 例（16.6%）为高级别或未分化肉瘤。我们在 17 例中确定了免疫组织化学标志物；5 例（29.4%）雌激素受体阳性，9 例（52.9%）孕激素受体阳性。CD10 在 10 例（58.8%）和 p53 在 11 例（64.7%）中表达。有 2 例与卵巢原发性肿瘤（乳头状囊腺癌）有关。总之，在我们的机构中，ESS 占 0.6%；大多数是低级别。p53、CD10 和激素受体等标志物的表达呈阳性。
