Lewiński A
Endokrinologie. 1978 May;72(2):175-82.
Influence of TRH, T3 and cGMP on the volume of thyrotropic cells nuclei in rat pituitary in vitro has been examined. A significant increase of the volume of thyrotropic cells nuclei in the culture exposed to TRH, in another one exposed to cGMP and in the third one exposed to both TRH and cGMP together have been observed. The mean volume of cells nuclei within the group exposed to T3 was significantly lower, when compared to the control. T3 inhibited the TRH-induced increase of the volume of thyrotrophs nuclei. The obtained results suggest that the role of cGMP and T3 in the regulation of the thyrotropic cell function are independent and rather opposed. Since TRH increases the level of cAMP in the anterior pituitary, additive effect of TRH and exogenous cGMP support the assumption that both the cyclic nucleotides within the thyrotropic cell act in the same direction.
已研究促甲状腺激素释放激素（TRH）、三碘甲状腺原氨酸（T3）和环磷酸鸟苷（cGMP）对体外培养的大鼠垂体促甲状腺细胞细胞核体积的影响。观察到暴露于TRH的培养物、暴露于cGMP的另一培养物以及同时暴露于TRH和cGMP的第三个培养物中促甲状腺细胞细胞核体积均显著增加。与对照组相比，暴露于T3的组中细胞核的平均体积显著更低。T3抑制TRH诱导的促甲状腺细胞核体积增加。所得结果表明，cGMP和T3在促甲状腺细胞功能调节中的作用是独立的，且相当相反。由于TRH会增加垂体前叶中cAMP的水平，TRH和外源性cGMP的相加作用支持了促甲状腺细胞内两种环核苷酸作用方向相同的假设。
