Messina Giuseppina, Anania Stefania, Bonomo Claudia, Veneroni Laura, Andreoli Antonietta, Mameli Francesca, Ortolina Chiara, De Fabritiis Paola, Gaffuri Maria, Imbesi Francesco, Moja Egidio
Psychological Service, Foundation IRCCS Ospedale Maggiore Policlinico, Milan, Italy.
Int J Yoga. 2011 Jan;4(1):33-8. doi: 10.4103/0973-6131.78181.
It has been shown that the pineal gland plays a fundamental role in mediating either the spiritual perception or the anticancer immunity by stimulating the endogenous production of anticancer cytokine interleukin (IL)-2.
The present study was performed to evaluate the impact of a spiritual approach consisting of Kriya Yoga program alone or in association with melatonin (MLT) or low-dose IL-2 plus MLT on the survival time in a group of metastatic cancer patients with life expectancy less than 1 year.
A case-control study was carried out in 240 patients (M/F: 146/94; median age: 62 years, range: 34-71, suffering from non-small-cell lung cancer or gastrointestinal tumors) who were subdivided into 6 groups of 40 patients, treated with supportive care alone as a control group, supportive care plus Yoga, MLT alone, MLT plus Yoga, inteleukin-2 plus MLT, or IL-2 plus MLT plus Yoga.
The best results in terms of increased survival time were obtained by the association between neuroimmunotherapy with MLT plus IL-2 and Yoga program (2 years), which was significantly longer with respect to that achieved by supportive care alone, Yoga alone, or IL-2 plus MLT alone (1 year).
This study would suggest that a spiritual therapeutic approach may improve the survival time of untreatable metastatic solid tumor patients.
研究表明，松果体通过刺激内源性抗癌细胞因子白细胞介素（IL）-2的产生，在介导精神感知或抗癌免疫方面发挥着重要作用。
本研究旨在评估仅进行克里亚瑜伽课程或联合褪黑素（MLT）或低剂量IL-2加MLT的精神疗法对一组预期寿命不足1年的转移性癌症患者生存时间的影响。
对240例患者（男/女：146/94；中位年龄：62岁，范围：34 - 71岁，患有非小细胞肺癌或胃肠道肿瘤）进行病例对照研究，将其分为6组，每组40例，分别接受单纯支持治疗作为对照组、支持治疗加瑜伽、单纯MLT、MLT加瑜伽、白细胞介素-2加MLT或IL-2加MLT加瑜伽治疗。
MLT加IL-2的神经免疫疗法与瑜伽课程联合使用时，在延长生存时间方面取得了最佳效果（2年），与单纯支持治疗、单纯瑜伽或单纯IL-2加MLT相比（1年），显著更长。
本研究表明，一种精神治疗方法可能会改善无法治疗的转移性实体瘤患者的生存时间。
