el-Mallakh R S, Jaziri W A
Department of Psychiatry, University of Connecticut Health Center, Farmington.
J Clin Psychopharmacol. 1990 Jun;10(3):203-6.
Available evidence suggests that verapamil and perhaps other calcium channel blockers are effective in treating mania but not unipolar depression. This article briefly reviews the clinical experience and reexamines potential mechanisms. It is proposed that antimanic efficacy is primarily related to inhibition of sodium-calcium counterexchange rather than calcium channel blockade.
现有证据表明，维拉帕米以及其他一些钙通道阻滞剂可能对治疗躁狂有效，但对单相抑郁症无效。本文简要回顾了临床经验并重新审视了潜在机制。研究表明，抗躁狂疗效主要与抑制钠钙逆向交换有关，而非钙通道阻滞。
