Division of Endocrinology and Metabolism, Department of Medicine, Kyung Hee University Hospital at Gangdong, Kyung Hee University School of Medicine, #149, Sangil-dong, Kangdong-ku, Seoul 134-727, South Korea.
Osteoporos Int. 2012 Apr;23(4):1337-42. doi: 10.1007/s00198-011-1679-x. Epub 2011 Jun 9.
In agreement with the results of animal studies, the plasma osteocalcin level is positively associated with improved glucose tolerance and insulin secretion and sensitivity. In addition, the plasma osteocalcin level is inversely associated with the development of diabetes; however, the plasma adiponectin level may not be involved in osteocalcin-mediated energy metabolism in humans.
Recent animal studies have suggested crosstalk between bone and energy metabolism through osteocalcin. The aims of this study were to determine whether or not osteocalcin is associated with the improved glucose tolerance and insulin secretion and sensitivity, and whether or not the association is dependent on the plasma adiponectin level in humans.
Four hundred twenty-five subjects, 19-82 years of age (mean age, 53 years), were enrolled. An oral glucose tolerance test (OGTT) and OGTT-based methods that were validated against the euglycemic clamp were determined. Total osteocalcin, leptin, and total adiponectin levels were measured.
The plasma levels of total osteocalcin were significantly different between the normal glucose tolerance, pre-diabetes, and diabetes groups. The glucose levels and homeostasis model assessment insulin resistance values varied inversely with the osteocalcin tertiles, and OGTT-based insulin secretion (HOMA-B%, disposition index) and insulin sensitivity indices (Stumvoll's and OGIS indices) were increased with the tertiles. Although the plasma adiponectin level was positively correlated with the osteocalcin level, no changes in the association were noted between the plasma osteocalcin level and the glucose tolerance or insulin secretion and sensitivity indices after adjustment for the plasma adiponectin level. Based on multiple logistic regression analysis, the plasma osteocalcin level was inversely associated with the development of type 2 diabetes mellitus independent of age, gender, body mass index, and fasting plasma glucose and plasma adiponectin levels.
Circulating osteocalcin level is associated with improved glucose tolerance and insulin secretion and sensitivity independent of the plasma adiponectin level in humans.
本研究旨在确定在人体中，骨钙素是否与改善的葡萄糖耐量和胰岛素分泌及敏感性相关，以及这种相关性是否依赖于血浆脂联素水平。
共纳入 425 例年龄为 19-82 岁（平均年龄为 53 岁）的受试者。进行口服葡萄糖耐量试验（OGTT）和基于 OGTT 的方法，并通过正葡萄糖钳夹技术进行验证。测定总骨钙素、瘦素和总脂联素水平。
总骨钙素的血浆水平在正常糖耐量、糖尿病前期和糖尿病组之间存在显著差异。血糖水平和稳态模型评估胰岛素抵抗值与骨钙素三分位呈反比变化，基于 OGTT 的胰岛素分泌（HOMA-B%、处置指数）和胰岛素敏感性指数（Stumvoll 指数和 OGIS 指数）随三分位的升高而增加。虽然血浆脂联素水平与骨钙素水平呈正相关，但在调整血浆脂联素水平后，血浆骨钙素水平与葡萄糖耐量或胰岛素分泌及敏感性指数之间的相关性没有变化。基于多因素 logistic 回归分析，血浆骨钙素水平与 2 型糖尿病的发生呈负相关，独立于年龄、性别、体重指数以及空腹血糖和血浆脂联素水平。
在人体中，循环骨钙素水平与改善的葡萄糖耐量和胰岛素分泌及敏感性相关，而不依赖于血浆脂联素水平。
