Jämstorp Erik, Strømme Maria, Frenning Göran
Division for Nanotechnology and Functional Materials, Department of Engineering Sciences, The Ångström Laboratory, Uppsala University, SE-75121 Uppsala, Sweden.
J Pharm Sci. 2011 Oct;100(10):4338-48. doi: 10.1002/jps.22636. Epub 2011 Jun 7.
A unique structure-function relationship investigation of mechanically strong geopolymer drug delivery vehicles for sustained release of potent substances is presented. The effect of in-synthesis water content on geopolymer pore structure and diffusive drug transport is investigated. Scanning electron microscopy, N2 gas adsorption, mercury intrusion porosimetry, compression strength test, drug permeation, and release experiments are performed. Effective diffusion coefficients are measured and compared with corresponding theoretical values as derived from pore size distribution and connectivity via pore-network modeling. By solely varying the in-synthesis water content, mesoporous and mechanically strong geopolymers with porosities of 8%-45% are obtained. Effective diffusion coefficients of the model drugs Saccharin and Zolpidem are observed to span two orders of magnitude (∼1.6-120 × 10(-8) cm(2) /s), comparing very well to theoretical estimations. The ability to predict drug permeation and release from geopolymers, and materials alike, allows future formulations to be tailored on a structural and chemical level for specific applications such as controlled drug delivery of highly potent substances.
本文介绍了一种针对用于强力物质持续释放的机械强度高的地质聚合物药物递送载体的独特结构-功能关系研究。研究了合成过程中的含水量对地质聚合物孔隙结构和药物扩散传输的影响。进行了扫描电子显微镜、N2气体吸附、压汞孔隙率测定、抗压强度测试、药物渗透和释放实验。测量了有效扩散系数，并与通过孔隙网络模型从孔径分布和连通性得出的相应理论值进行比较。仅通过改变合成过程中的含水量，就获得了孔隙率为8%-45%的中孔且机械强度高的地质聚合物。观察到模型药物糖精和唑吡坦的有效扩散系数跨越两个数量级（约1.6-120×10(-8) cm(2)/s），与理论估计值非常吻合。预测地质聚合物及类似材料中药物渗透和释放的能力，使得未来的配方能够在结构和化学层面上针对特定应用进行定制，例如高效能物质的控释给药。
