Antonova N P, Lazareva N P, Kalita N F, Petrova E A
Vopr Pitan. 1990 Mar-Apr(2):41-4.
The influence of vitamin D and ultraviolet irradiation (UVI), used for prevention of vitamin D deficiency, on the state of phosphoric-calcium metabolism was studied in experiments on rats. It has been shown that daily injections of 1-5 IU of vitamin D, and UVI in biodoses from 1/8 to 1/4 promote the maintainance of the normal level of phosphoric-calcium metabolism. When UVI was applied according to the widely used "basic scheme" (in biodoses from 1/4 to 2 1/2) the following anomalies were recorded: a three-fold increase of 25-ON-D3 concentration in the blood plasma, hyperphosphatemia, a tendency to hypercalcemia. The use of higher doses of UVI led to a further increase of 25-OH-D3 level, hypophosphatemia, hypercalcemia, kidney and heart calcification. The data obtained have evidenced a possibility of vitamin D intoxication during UVI.
在大鼠实验中，研究了用于预防维生素D缺乏的维生素D和紫外线照射（UVI）对磷酸钙代谢状态的影响。结果表明，每日注射1 - 5国际单位的维生素D以及生物剂量为1/8至1/4的紫外线照射可促进维持磷酸钙代谢的正常水平。当按照广泛使用的“基本方案”（生物剂量为1/4至2 1/2）应用紫外线照射时，记录到以下异常情况：血浆中25 - ON - D3浓度增加三倍、高磷血症、有高钙血症倾向。使用更高剂量的紫外线照射导致25 - OH - D3水平进一步升高、低磷血症、高钙血症、肾脏和心脏钙化。所获得的数据证明了紫外线照射期间维生素D中毒的可能性。
