抗寄生虫免疫反应中的嗜碱性粒细胞。
Basophils in immune responses against helminths.
机构信息
Department of Infection Biology, Institute of Clinical Microbiology, Immunology and Hygiene, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany.
出版信息
Microbes Infect. 2011 Oct;13(11):881-7. doi: 10.1016/j.micinf.2011.05.001. Epub 2011 May 27.
PMID:21658463
Abstract
Basophils are a major source of IL-4 and IL-13, two key cytokines that orchestrate expulsion of gastrointestinal nematodes in different mouse models. Based on recent reports, this review discusses potential roles of basophils and other cells during early and late phases of the immune response against parasitic worms.
摘要
嗜碱性粒细胞是白细胞介素 4（IL-4）和白细胞介素 13（IL-13）的主要来源，这两种关键细胞因子在不同的小鼠模型中协调了对胃肠道线虫的驱逐。基于最近的报告，这篇综述讨论了嗜碱性粒细胞和其他细胞在针对寄生虫的免疫反应的早期和晚期阶段的潜在作用。
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