Department of Biological Sciences, Institute of Applied Sciences, University of North Texas, PO Box 310559, Denton, TX 76203, USA.
Chemosphere. 2011 Sep;84(10):1371-7. doi: 10.1016/j.chemosphere.2011.05.008. Epub 2011 Jun 11.
Pharmaceutical products and their metabolites are being widely detected in aquatic environments and there is a growing interest in assessing potential risks of these substances to fish and other non-target species. Ibuprofen is one of the most commonly used analgesic drugs and no peer-reviewed laboratory studies have evaluated the tissue specific bioconcentration of ibuprofen in fish. In the current study, fathead minnow (Pimephales promelas) were exposed to 250 μg L(-1) ibuprofen for 28 d followed by a 14 d depuration phase. In a minimized bioconcentration test design, channel catfish (Ictalurus punctatus) were exposed to 250 μg L(-1) for a week and allowed to depurate for 7 d. Tissues were collected during uptake and depuration phases of each test and the corresponding proportional and kinetic bioconcentration factors (BCFs) were estimated. The results indicated that the BCF levels were very low (0.08-1.4) implying the lack of bioconcentration potential for ibuprofen in the two species. The highest accumulation of ibuprofen was observed in the catfish plasma as opposed to individual tissues. The minimized test design yielded similar bioconcentration results as those of the standard test and has potential for its use in screening approaches for pharmaceuticals and other classes of chemicals.
药品及其代谢物广泛存在于水生环境中，人们越来越关注这些物质对鱼类和其他非目标物种的潜在风险。布洛芬是最常用的止痛药之一，但目前还没有经过同行评审的实验室研究评估布洛芬在鱼类组织中的特异性生物浓缩情况。在当前的研究中，采用脂鲤（Pimephales promelas）进行 250μg/L 的布洛芬暴露实验，持续 28 天，随后进行 14 天的净化阶段。在最小化的生物浓缩测试设计中，采用斑点叉尾鮰（Ictalurus punctatus）进行 250μg/L 的暴露实验，持续一周，然后进行 7 天的净化。在每个测试的摄取和净化阶段收集组织，并估计相应的比例和动力学生物浓缩系数（BCF）。结果表明，BCF 水平非常低（0.08-1.4），这意味着布洛芬在这两个物种中没有生物浓缩潜力。布洛芬在斑点叉尾鮰的血浆中的积累最高，而不是在单个组织中。最小化的测试设计与标准测试产生了相似的生物浓缩结果，并且有可能用于筛选药品和其他类别的化学物质。
