Department of Gynecology-Obstetrics, 30 boulevard de la Cluse, Faculty of Medicine, Geneva 14, Switzerland.
Cancer Lett. 2011 Oct 1;309(1):104-9. doi: 10.1016/j.canlet.2011.05.022. Epub 2011 Jun 11.
Circulating glucose-regulated protein 78 (GRP78) autoantibodies represent potential biomarker of epithelial ovarian cancer. However there is relatively limited identification of these antibodies in response to ovarian cancer. Here, we were interested in characterization of these antibodies and into their role in tumor development. We first purified GRP78 autoantibodies from sera of patients with ovarian cancer, and then tested them on SKOV-3 ovarian cancer cell line. A decrease of invasion and an increase of H(2)O(2)-induced apoptosis of SKOV-3 cells were observed, suggesting their protective role against ovarian cancer cells.
循环葡萄糖调节蛋白 78（GRP78）自身抗体是上皮性卵巢癌潜在的生物标志物。然而，针对这些抗体的识别相对有限。在这里，我们对这些抗体的特性及其在肿瘤发展中的作用感兴趣。我们首先从卵巢癌患者的血清中纯化 GRP78 自身抗体，然后在 SKOV-3 卵巢癌细胞系上进行测试。观察到 SKOV-3 细胞的侵袭减少和 H₂O₂诱导的凋亡增加，表明它们对卵巢癌细胞具有保护作用。
