甘油磷酸胆碱磷酸二酯酶活性在多发性硬化斑块中降低。
Glycerylphosphocholine phosphocholine phosphodiesterase activity is reduced in multiple sclerosis plaques.
作者信息
Janzen L, Tourtellotte W W, Kanfer J N
机构信息
University of Manitoba, Winnipeg, Canada.
出版信息
Exp Neurol. 1990 Aug;109(2):243-6. doi: 10.1016/0014-4886(90)90079-8.
PMID:2165915
Abstract
Glycerylphosphorylcholine (GPC) phosphocholine phosphodiesterase activity (EC 3.1.4.38) is significantly reduced in multiple sclerosis plaques compared to adjacent tissue with a P less than 0.01 based upon the Student-Newman-Keuls or Tukey test. This finding is in accord with the proposal that this particular form of the enzyme is myelin-specific. Similar activities for GPC phosphocholine phosphodiesterase were obtained with samples from various regions of the same individual brain.
摘要
与相邻组织相比，甘油磷酸胆碱（GPC）磷酸胆碱磷酸二酯酶活性（EC 3.1.4.38）在多发性硬化斑块中显著降低，根据学生-纽曼-基尔斯检验或图基检验，P值小于0.01。这一发现与该酶的这种特定形式是髓鞘特异性的这一观点一致。从同一个体大脑的不同区域获取的样本中，GPC磷酸胆碱磷酸二酯酶的活性相似。
相似文献
1
Glycerylphosphocholine phosphocholine phosphodiesterase activity is reduced in multiple sclerosis plaques.甘油磷酸胆碱磷酸二酯酶活性在多发性硬化斑块中降低。
Exp Neurol. 1990 Aug;109(2):243-6. doi: 10.1016/0014-4886(90)90079-8.
2
2',3'-cyclic nucleotide 3'-phosphodiesterase in CNS and PNS myelin: two molecular forms.中枢神经系统和周围神经系统髓鞘中的2',3'-环核苷酸3'-磷酸二酯酶：两种分子形式。
J Neurochem. 1986 Dec;47(6):1963. doi: 10.1111/j.1471-4159.1986.tb13115.x.
3
Glycerophosphorylcholine phosphocholine phosphodiesterase activity in cultured oligodendrocytes, astrocytes, and central nervous tissue of dysmyelinating rodent mutants.脱髓鞘啮齿动物突变体的培养少突胶质细胞、星形胶质细胞和中枢神经组织中的甘油磷酸胆碱磷酸二酯酶活性
J Neurosci Res. 1992 Jan;31(1):68-74. doi: 10.1002/jnr.490310110.
4
2',3'-Cyclic nucleotide 3'-phosphohydrolase and lipids of myelin from multiple sclerosis and normal brains.来自多发性硬化症患者和正常大脑的髓磷脂中的2',3'-环核苷酸3'-磷酸水解酶与脂质
J Neurochem. 1980 Mar;34(3):732-9. doi: 10.1111/j.1471-4159.1980.tb11205.x.
5
Analysis of kinetic parameters of cyclic nucleotide phosphodiesterase systems by fast atom bombardment tandem mass spectrometry.通过快原子轰击串联质谱法分析环核苷酸磷酸二酯酶系统的动力学参数
Biochem Soc Trans. 1991 Nov;19(4):397S. doi: 10.1042/bst019397s.
6
Effects of detergents, proteins, and lipids on 2':3'-cyclic-nucleotide 3'-phosphodiesterase activity.去污剂、蛋白质和脂质对2':3'-环核苷酸3'-磷酸二酯酶活性的影响。
J Neurochem. 1980 Jul;35(1):164-9. doi: 10.1111/j.1471-4159.1980.tb12502.x.
7
A sensitive fluorometric assay for 2',3'-cyclic nucleotide 3'-phosphohydrolase.一种用于2',3'-环核苷酸3'-磷酸水解酶的灵敏荧光测定法。
J Neurochem. 1980 Aug;35(2):503-5. doi: 10.1111/j.1471-4159.1980.tb06294.x.
8
Detergent activation and solubilization of 2':3'-cyclic nucleotide 3'-phosphodiesterase from isolated myelin and c6 cells.去污剂对分离的髓磷脂和C6细胞中2':3'-环核苷酸3'-磷酸二酯酶的激活及增溶作用
Biochem J. 1979 Aug 1;181(2):367-75. doi: 10.1042/bj1810367.
9
2', 3'-cyclic nucleotide 3'-phosphohydrolase activity in brain of acute experimental allergic encephalomyelitis.急性实验性过敏性脑脊髓炎脑内的2', 3'-环核苷酸3'-磷酸水解酶活性
Brain Res. 1979 Jun 29;169(3):620-4. doi: 10.1016/0006-8993(79)90416-5.
10
Neurochemical characteristics of myelin-like structure in the chick retina.鸡视网膜中髓磷脂样结构的神经化学特征
J Neurochem. 1980 Mar;34(3):662-8. doi: 10.1111/j.1471-4159.1980.tb11195.x.
引用本文的文献
1
Bovine brain myelin glycerophosphocholine choline phosphodiesterase is an alkaline lysosphingomyelinase of the eNPP-family, regulated by lysosomal sorting.牛脑髓鞘甘油磷酰胆碱磷酸二酯酶是一种碱性溶酶体鞘磷脂酶，属于 eNPP 家族，受溶酶体分拣调节。
Neurochem Res. 2013 Feb;38(2):300-10. doi: 10.1007/s11064-012-0921-z. Epub 2012 Nov 17.
2
Oxidative inactivation of brain ecto-5'-nucleotidase by thiols/Fe2+ system.硫醇/Fe2+ 体系对脑外5'-核苷酸酶的氧化失活作用
Neurochem Res. 2000 Nov;25(11):1475-84. doi: 10.1023/a:1007624125136.
3
Active site of brain Zn2+-glycerophosphocholine cholinephosphodiesterase and regulation of enzyme activity.脑锌离子 - 甘油磷酸胆碱胆碱磷酸二酯酶的活性位点及酶活性调节
Neurochem Res. 1998 Aug;23(8):1061-7. doi: 10.1023/a:1020755918632.
4
Interaction of divalent metal ions with Zn(2+)-glycerophosphocholine cholinephosphodiesterase from ox brain.二价金属离子与牛脑锌（2+）-甘油磷酸胆碱胆碱磷酸二酯酶的相互作用。
Neurochem Res. 1997 Dec;22(12):1471-6. doi: 10.1023/a:1021902428146.
5
Properties of a Zn(2+)-glycerophosphocholine cholinephosphodiesterase from bovine brain membranes.来自牛脑膜的锌离子甘油磷酸胆碱胆碱磷酸二酯酶的特性
Neurochem Res. 1996 Oct;21(10):1193-9. doi: 10.1007/BF02532395.
6
Multiple forms of the enzyme glycerophosphodiesterase are present in human brain.人类大脑中存在多种形式的甘油磷酸二酯酶。
Lipids. 1995 Dec;30(12):1075-81. doi: 10.1007/BF02536607.
7
Purification and properties of a glycerophosphocholine phosphodiesterase from bovine brain myelin.牛脑髓鞘甘油磷酸胆碱磷酸二酯酶的纯化及性质
Neurochem Res. 1994 Jan;19(1):43-8. doi: 10.1007/BF00966727.
8
Involvement of both a Zn2+ site and an anionic binding site in the selective inhibition of a Zn(2+)-glycerophosphocholine cholinephosphodiesterase by thiols and tellurites.锌离子位点和阴离子结合位点参与硫醇和亚碲酸盐对锌（2+）-甘油磷酸胆碱胆碱磷酸二酯酶的选择性抑制作用。
Neurochem Res. 1995 Feb;20(2):151-7. doi: 10.1007/BF00970539.
9
Characterization of a Zn(2+)-requiring glycerophosphocholine cholinephosphodiesterase possessing p-nitrophenylphosphocholine phosphodiesterase activity.一种具有对硝基苯磷酸胆碱磷酸二酯酶活性的、需要锌离子的甘油磷酸胆碱胆碱磷酸二酯酶的特性研究
Biochem J. 1992 Sep 1;286 ( Pt 2)(Pt 2):435-40. doi: 10.1042/bj2860435.
Zotero 插件