Besser R, Vogt T, Gutmann L
Department of Neurology, University of Mainz, West Germany.
Neurology. 1990 Aug;40(8):1275-7. doi: 10.1212/wnl.40.8.1275.
Two patients with acute severe organophosphate intoxication showed (1) single evoked compound muscle action potentials (CMAP) with repetitive discharges and (2) prominent decremental responses of CMAP with 20 and 50 Hz supramaximal nerve stimulation. Following the intravenous injection of single small doses of pancuronium, marked improvement in these abnormalities occurred and persisted for several hours. We postulate that the physiologic improvement following low-dose pancuronium results from blockade of acetylcholine receptors, especially those located on the terminal axon responsible for antidromic backfiring.
（1）单次诱发的复合肌肉动作电位（CMAP）伴有重复放电；（2）在20和50 Hz超强神经刺激下，CMAP出现明显的递减反应。静脉注射小剂量潘库溴铵后，这些异常情况有显著改善，并持续数小时。我们推测，低剂量潘库溴铵后的生理改善是由于乙酰胆碱受体被阻断，尤其是位于负责逆向回射的轴突末端的受体。
