ω-芋螺毒素对牛嗜铬细胞钙电流的阻断作用。
The blocking effects of omega-conotoxin on Ca current in bovine chromaffin cells.
作者信息
Hans M, Illes P, Takeda K
机构信息
Université Louis Pasteur de Strasbourg, Laboratoire de Pharmacologie Cellulaire et Moléculaire-CNRS, Illkirch, France.
出版信息
Neurosci Lett. 1990 Jun 22;114(1):63-8. doi: 10.1016/0304-3940(90)90429-d.
The effects of omega-conotoxin (omega-CgTX) on voltage-sensitive Ca currents (ICa) were studied in cultured bovine adrenal chromaffin cells. A maximal block of ICa of 40-50% was obtained with omega-CgTX in the microM range, and was independent of the holding potential. The onset of block was both concentration- and time-dependent. In bovine chromaffin cells, Ca channels, both sensitive and insensitive to omega-CgTX, appear to be present.
在培养的牛肾上腺嗜铬细胞中研究了ω-芋螺毒素（ω-CgTX）对电压敏感性钙电流（ICa）的影响。在微摩尔范围内，ω-CgTX可使ICa最大阻断40%-50%，且与钳制电位无关。阻断的起始既与浓度有关也与时间有关。在牛嗜铬细胞中，似乎同时存在对ω-CgTX敏感和不敏感的钙通道。
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