顺铂 - 核苷酸复合物的辐射化学
Radiation chemistry of cis-platinum-nucleotide complexes.
作者信息
Anastassopoulou J D, Brekoulakis J S
机构信息
National Technical University of Athens, Laboratory of Radiation Chemistry and Biospectroscopy, Greece.
出版信息
Anticancer Res. 1990 Jul-Aug;10(4):983-6.
The mechanism of gamma-radiolysis of cis-dichlorodiammineplatinum (II) (cis-Platinum) with guanosine-5'-monophosphate (L) complexes in aqueous solutions was investigated. The decomposition limiting yield G (-cis-Pt (NH3)2L2) in deaerated and nitrous oxide saturated solutions, determined by measuring the absorbance at 254 nm, was found to be 0.8 and 1.2, respectively. It was found from HPLC that, upon irradiation of the complexes, guanosine-5'-monophosphate, guanosine and guanine were released. Other products, such as sugarphosphate and sugar, could not be detected with this UV-method.
研究了水溶液中顺式二氯二氨合铂（II）（顺铂）与5'-鸟苷单磷酸（L）配合物的γ辐解机理。通过测量254nm处的吸光度确定，在脱气和一氧化二氮饱和溶液中分解极限产率G（-顺式-Pt(NH3)2L2）分别为0.8和1.2。通过高效液相色谱法发现，辐照配合物时会释放出5'-鸟苷单磷酸、鸟苷和鸟嘌呤。用这种紫外方法无法检测到其他产物，如磷酸糖和糖。
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