Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol, QLD, Australia.
Semin Cell Dev Biol. 2011 Aug;22(6):629-36. doi: 10.1016/j.semcdb.2011.05.004. Epub 2011 Jun 6.
In this review we will provide a concise summary of the evidence implicating a role for vitamin D in the developing brain. Vitamin D is known to affect a diverse array of cellular functions. Over the past 10 years data has emerged implicating numerous ways in which this vitamin could also affect the developing brain including its effects on cell differentiation, neurotrophic factor expression, cytokine regulation, neurotransmitter synthesis, intracellular calcium signaling, anti-oxidant activity, and the expression of genes/proteins involved in neuronal differentiation, structure and metabolism. Dysfunction in any of these processes could adversely affect development. Although there are many ways to study the effects of vitamin D on the developing CNS in vivo, we will concentrate on one experimental model that has examined the impact of the dietary absence of vitamin D in utero. Finally, we discuss the epidemiological data that suggests that vitamin D deficiency either in utero or in early life may have adverse neuropsychiatric implications.
在这篇综述中，我们将简要总结维生素 D 对发育中大脑的作用的证据。已知维生素 D 会影响多种细胞功能。在过去的 10 年中，有数据表明这种维生素还可以通过多种方式影响发育中的大脑，包括对细胞分化、神经营养因子表达、细胞因子调节、神经递质合成、细胞内钙信号转导、抗氧化活性以及参与神经元分化、结构和代谢的基因/蛋白质的表达的影响。这些过程中的任何一个功能障碍都可能对发育产生不利影响。尽管有许多方法可以在体内研究维生素 D 对发育中中枢神经系统的影响，但我们将集中讨论一个实验模型，该模型研究了母体缺乏维生素 D 对胎儿的影响。最后，我们讨论了流行病学数据，表明母体或婴儿早期维生素 D 缺乏可能会对神经精神产生不良影响。
