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玻璃体内注射贝伐单抗治疗儿童创伤后脉络膜新生血管化

Intravitreal bevacizumab for posttraumatic choroidal neovascularization in a child.

作者信息

Piermarocchi Stefano, Benetti Elisa, Fracasso Gianfranco

机构信息

Department of Neurosciences, Ophthalmology Unit, University of Padua, Padua, Italy.

出版信息

J AAPOS. 2011 Jun;15(3):314-6. doi: 10.1016/j.jaapos.2011.02.008. Epub 2011 Jun 12.

DOI:10.1016/j.jaapos.2011.02.008
PMID:21665504
Abstract

Choroidal neovascularization, an uncommon occurrence in children, may complicate up to 20% of cases of closed-globe blunt trauma with Bruch's membrane rupture. Visual outcome in untreated eyes is usually poor, and there is no consensus on the management of this complication. Treatment options include observation, surgical removal of the membrane, photocoagulation, or photodynamic therapy. Antivascular endothelial growth factor therapy has recently been proposed in sporadic adult cases. We report a case of post-traumatic choroidal neovascularization in a boy that has was successfully treated with intravitreal bevacizumab.

摘要

脉络膜新生血管形成在儿童中并不常见,在伴有 Bruch 膜破裂的闭合性眼球钝挫伤病例中,其发生率可能高达 20%。未经治疗的眼睛视力预后通常较差,对于这种并发症的处理尚无共识。治疗选择包括观察、手术切除膜、光凝或光动力疗法。抗血管内皮生长因子疗法最近在散发性成人病例中被提出。我们报告一例男孩创伤后脉络膜新生血管形成,经玻璃体内注射贝伐单抗成功治疗。

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引用本文的文献

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A case of expansion of traumatic choroidal rupture with delayed-developed outer retinal changes.一例伴有迟发性视网膜外层改变的外伤性脉络膜破裂扩大病例。
Case Rep Ophthalmol. 2013 Aug 6;4(2):70-5. doi: 10.1159/000354197. eCollection 2013.
2
Choroidal neovascularization in 36 eyes of children and adolescents.36 只儿童和青少年眼的脉络膜新生血管。
Eye (Lond). 2013 Oct;27(10):1158-68. doi: 10.1038/eye.2013.155. Epub 2013 Jul 26.