Hertel A, Baum R P, Lorenz M, Baew-Christow T, Encke A, Hör G
Department of Nuclear Medicine, Johann Wolfgang Goethe University Medical Center, Frankfurt/Main, FRG.
Br J Cancer Suppl. 1990 Jul;10:34-6.
Using the intact monoclonal IgG1 anti-CEA antibody BW 431/26 (Behringwerke Marburg, FRG) labelled with 99mTc by a new labelling procedure (Schwarz method), 72 patients suspected of tumour recurrences (colorectal cancer, n = 59) and with rising serum carcinoembryonic antigen (CEA) levels were studied. Sixty-nine of 72 studies had a positive result by immunoscintigraphy of which 52 have since been proven histologically/clinically. In six patients only immunoscintigraphy revealed a tumour recurrence while all other diagnostic modalities were negative. Of 52 studies 46 were true positive (diagnostic sensitivity 88%). In this series there was one false positive result. About one-third of all patients injected with the antibody developed a human anti-mouse response (HAMA), but no severe side effects were seen even after four applications. For the follow-up of colorectal and other CEA positive adenocarcinomas this 99mTc-labelled monoclonal antibody seems to be very promising in patients with rising serum CEA, especially if conventional diagnostic imaging procedures remain negative.
采用一种新的标记方法（施瓦茨法），用⁹⁹ᵐTc标记完整的单克隆IgG1抗癌胚抗原（CEA）抗体BW 431/26（德国马尔堡贝林werke公司），对72例怀疑肿瘤复发（结肠癌，n = 59）且血清癌胚抗原（CEA）水平升高的患者进行了研究。72例研究中有69例免疫闪烁显像结果为阳性，其中52例随后经组织学/临床证实。6例患者仅免疫闪烁显像显示肿瘤复发，而所有其他诊断方法均为阴性。52例研究中有46例为真阳性（诊断敏感性88%）。该系列中有1例假阳性结果。所有注射该抗体的患者中约三分之一出现人抗鼠反应（HAMA），但即使在四次应用后也未观察到严重副作用。对于结直肠癌和其他CEA阳性腺癌的随访，这种⁹⁹ᵐTc标记的单克隆抗体在血清CEA升高的患者中似乎非常有前景，特别是在传统诊断成像程序仍为阴性的情况下。
