Lin J S
Tianjin Medical College.
Zhonghua Bing Li Xue Za Zhi. 1990 Mar;19(1):67-70.
Eighteen cases of pleomorphic sarcoma diagnosed or supposed as rhabdomyosarcomas (RMS) and fourteen cases of other soft tissue lesions were stained with five specific antisera (myoglobin, desmin, alpha-1-antitrypsin, Lysozyme, and S-100) by peroxidase antiperoxidase method. The immunohistochemical findings indicated that the majority of the pleomorphic sarcomas (11/18) had to be reclassified as malignant fibrous histiocytoma (MFH), and pleomorphic RMS was indeed rare in adults over the age of 30 years. In this MFH group, desmin was present in all but 3 cases (8/11), supporting that MFH is a tumor originated from mesenchymal cells other than histiocytes. The success of using immunohistochemistry for making pathologic diagnosis depends upon rational application of panels of antibodies. The diagnostic features of pleomorphic sarcomas in routine or special stains are discussed.
18例诊断为或疑似横纹肌肉瘤（RMS）的多形性肉瘤及14例其他软组织病变，采用过氧化物酶抗过氧化物酶法用5种特异性抗血清（肌红蛋白、结蛋白、α1抗胰蛋白酶、溶菌酶和S-100）进行染色。免疫组化结果表明，大多数多形性肉瘤（11/18）不得不重新分类为恶性纤维组织细胞瘤（MFH），30岁以上成人中多形性RMS确实罕见。在该MFH组中，除3例（8/11）外所有病例均有结蛋白表达，支持MFH是一种起源于组织细胞以外间充质细胞的肿瘤。应用免疫组化进行病理诊断的成功取决于合理应用抗体组合。讨论了多形性肉瘤在常规或特殊染色中的诊断特征。
