Huang W M, Zhang Z H, Xu Y Q
Cardiovascular Research Laboratory Xu Hui District Central Hospital, Shanghai, P.R. China.
J Electrocardiol. 1990 Jul;23(3):231-4. doi: 10.1016/0022-0736(90)90161-t.
The effects of berberine on slow-response action potentials (SAP) of guinea pig papillary muscles were studied. SAP was elicited by histamine in a high concentration of potassium solution (27 mmol). The results showed that berberine (24.5 mumol) was able to increase action potential amplitude, maximum rate of depolarization, action potential duration 50, action potential duration 100 (n = 16, p less than 0.01) and effective refractory period (n = 10, p less than 0.01) of SAP by 6.2%, 21.1%, 50.1%, 47.2% and 92.2%, respectively, but did not affect the resting membrane potential (RMP). To the above parameters, except APD 100, berberine was no longer to induce any significant change by pretreating with propranolol. The results suggested that the effects of berberine on slow-response action potentials were mainly related to the facilitating of slow calcium inward current, which might result from stimulating the beta-adrenoceptor.
研究了黄连素对豚鼠乳头肌慢反应动作电位（SAP）的影响。在高钾溶液（27 mmol）中用组胺诱发SAP。结果表明，黄连素（24.5 μmol）能够使SAP的动作电位幅度、最大去极化速率、动作电位持续时间50、动作电位持续时间100（n = 16，p < 0.01）和有效不应期（n = 10，p < 0.01）分别增加6.2%、21.1%、50.1%、47.2%和92.2%，但不影响静息膜电位（RMP）。对于上述参数，除动作电位持续时间100外，用普萘洛尔预处理后黄连素不再引起任何显著变化。结果提示，黄连素对慢反应动作电位的影响主要与促进慢钙内向电流有关，这可能是通过刺激β - 肾上腺素能受体实现的。
