Sing K P, Gautam S K
Arzneimittelforschung. 1977;27(10):2002-5.
The antidepressant characteristics of three indole alkylamines were investigated and compared with phenelzine and imipramine by utilising specific pharmacological tools like reserpine, amphetamine, tryptamine and tetrabenazine for determining their possible mechanism of action. Amongst the three indole compounds investigated, indole-3-(2-aminopropyl)-acetate (U-14 164E), indole-3(2-aminobutyl)-d-acetate (u-17 312E) and beta-phenethylhydrazine (phenelzine) produced complete antagonism to reserpine induced sedation, hypothermia as well as facilitation of convulsive seizures. Some of these features suggest that MAO inhibition might be a common mechanism of action of these indoles. The potentiation of CNS effects of tryptamine by these compounds is an outstanding feature of MAO inhibitors, while imipramine is ineffective. Qualitative differences between these indoles and imipramine are evident in the tetrabenazine test. The potentiation of amphetamine induced motor excitation and pentobarbitone narcosis has been explained.
利用利血平、苯丙胺、色胺和丁苯那嗪等特定药理学工具，研究并比较了三种吲哚烷基胺与苯乙肼和丙咪嗪的抗抑郁特性，以确定它们可能的作用机制。在所研究的三种吲哚化合物中，吲哚 - 3 -（2 - 氨基丙基） - 乙酸酯（U - 14 164E）、吲哚 - 3（2 - 氨基丁基） - d - 乙酸酯（u - 17 312E）和β - 苯乙肼（苯乙肼）对利血平诱导的镇静、体温过低以及惊厥发作的促进作用产生了完全拮抗作用。这些特征中的一些表明，单胺氧化酶抑制可能是这些吲哚的共同作用机制。这些化合物对色胺中枢神经系统作用的增强是单胺氧化酶抑制剂的一个显著特征，而丙咪嗪则无效。在丁苯那嗪试验中，这些吲哚与丙咪嗪之间的定性差异很明显。已经解释了苯丙胺诱导的运动兴奋和戊巴比妥麻醉的增强作用。
