Department of Orthopaedics and Traumatology, Catholic University, Rome.
Int J Immunopathol Pharmacol. 2011 Jan-Mar;24(1 Suppl 2):91-4. doi: 10.1177/03946320110241S217.
Prosthetic joints loosening in absence of infection is the most common reason for revision surgery and is known as aseptic loosening. A significant role in the pathogenesis of implant failure undoubtedly played by the generation of wear debris, mainly from the load bearing joint surfaces, and the cellular reaction through the formation of tissue membrane around implants. This article analyzes histologic, immunohistochemical ad ultrastructural aspects of periprosthetic tissue membrane collected at time of surgical revision, paying attention on cell host response to different materials: metals, polyethylene and ceramics. Dimension of particles seems to be crucial in the activation of different cell population to wear debris.
人工关节在无感染的情况下松动是翻修手术最常见的原因，这种情况被称为无菌性松动。在植入物失效的发病机制中，磨损颗粒的产生无疑起着重要作用，这些颗粒主要来自承重关节表面，通过在植入物周围形成组织膜来引发细胞反应。本文分析了外科翻修时收集的假体周围组织膜的组织学、免疫组织化学和超微结构方面，重点关注不同材料（金属、聚乙烯和陶瓷）对宿主细胞的反应。颗粒的尺寸似乎对磨损颗粒激活不同细胞群起着关键作用。
