Department of Histology and Embryology, Chongqing Medical University, Chongqing, PR China.
Neurosci Lett. 2011 Jul 25;499(3):208-12. doi: 10.1016/j.neulet.2011.05.229. Epub 2011 Jun 6.
Efficient and unbiased stereological methods were used to study the age-related changes of corpus callosum and the age-related changes of the myelinated fibers in the corpus callosum. There existed age-related atrophy of rat corpus callosum. The total volume of the myelinated fibers and the total volume of the myelin sheathes in the corpus callosum of aged rat were significantly decreased when compared to young rat. The age-related changes of corpus callosum were primarily due to the loss of the myelinated fibers with small diameters.
采用高效、无偏的体视学方法研究了胼胝体的年龄相关性变化以及胼胝体髓鞘纤维的年龄相关性变化。大鼠胼胝体存在与年龄相关的萎缩。与年轻大鼠相比，老年大鼠胼胝体的有髓纤维总容积和髓鞘总容积显著减少。胼胝体的年龄相关性变化主要是由于小直径有髓纤维的丢失所致。
