Marine Drug & Food Institute, Ocean University of China, 5 Yu shan Road, Qingdao 266003, PR China.
Eur J Med Chem. 2011 Sep;46(9):3851-7. doi: 10.1016/j.ejmech.2011.05.053. Epub 2011 May 30.
A novel dissymmetrical N,N'-bis(substituted)oxamide ligand, N-(2-aminopropyl)-N'-(2-oxido- phenyl)oxamide (H(3)apopoxd) (L), and its three bicopper(II) complexes, [Cu(2)(apopoxd)(bpy)]- (ClO(4))·H(2)O (1), Cu(2)(apopoxd)(dabt)·2H(2)O (2), and Cu(2)(apopoxd)(phen)(2) (3) (bpy = 2,2'-bipyridine; dabt = 2,2'-diamino-4,4'-bithiazole; phen = 1,10-phenanthroline) have been synthesized and characterized. The crystal structures of the three bicopper(II) complexes have been determined by X-ray single-crystal diffraction. In complexes 1 and 2, the cis-apopoxd(3-) ligands bridge two copper(II) ions in square-planar geometries with the corresponding separations of 5.1868(3) and 5.2016(4) Å, respectively. While in complex 3, the apopoxd(3-) ligand adopting a trans conformation bridges the two copper(II) ions in distorted square-pyramid environments with a Cu · · · Cu distance of 5.2508(7) Å. The anticancer activities and DNA-binding properties of L and the three complexes were investigated.
一种新型不对称 N,N'-双（取代）氧酰胺配体，N-(2-氨基丙基）-N'-(2-氧代苯基）氧酰胺（H(3)apopoxd）（L），及其三个双铜（II）配合物，[Cu(2)(apopoxd)(bpy)]-（ClO(4))·H(2)O (1)，Cu(2)(apopoxd)(dabt)·2H(2)O (2)，和Cu(2)(apopoxd)(phen)(2) (3)（bpy = 2,2'-联吡啶；dabt = 2,2'-二氨基-4,4'-联噻唑；phen = 1,10-菲咯啉）已被合成和表征。通过 X 射线单晶衍射确定了三个双铜（II）配合物的晶体结构。在配合物 1 和 2 中，顺式-apopoxd(3-)配体以正方形平面几何构型桥接两个铜（II）离子，相应的分离距离分别为 5.1868(3)和 5.2016(4)Å。而在配合物 3 中，apopoxd(3-)配体采用反式构象，以扭曲的四方锥环境桥接两个铜（II）离子，Cu···Cu 距离为 5.2508(7)Å。研究了 L 和三个配合物的抗癌活性和 DNA 结合特性。
