Division of Pulmonology, Department of Internal Medicine, Medical University of Graz, Austria.
Cancer Lett. 2011 Sep 28;308(2):134-43. doi: 10.1016/j.canlet.2011.03.014. Epub 2011 Jun 12.
Hypoxia frequently occurs in solid tumors and is known to contribute to chemotherapy resistance. However, the mechanisms leading to chemotherapy resistance are not entirely known. We investigated hypoxia-induced resistance to cisplatin in NSCLC cell lines. We show that chronic moderate hypoxia induced resistance to cisplatin in NSCLC cells without involvement of selection pressure. Our data suggest that stabilization of the hypoxia-inducible factor 1 alpha and down-regulation of the pro-apoptotic protein BAX play a role in this process. Furthermore, we provide evidence that hypoxia-induced resistance to cisplatin is not due to the reduced growth rate of cancer cells under hypoxic conditions.
缺氧在实体肿瘤中经常发生，已知其会导致化疗耐药。然而，导致化疗耐药的机制尚不完全清楚。我们研究了缺氧诱导的非小细胞肺癌细胞系对顺铂的耐药性。我们表明，慢性中度缺氧在没有选择压力的情况下诱导了非小细胞肺癌细胞对顺铂的耐药性。我们的数据表明，缺氧诱导因子 1α 的稳定和促凋亡蛋白 BAX 的下调在这个过程中起作用。此外，我们提供的证据表明，缺氧诱导的顺铂耐药性不是由于缺氧条件下癌细胞生长速度的降低所致。
