依诺昔酮与二丁酰环磷腺苷对大鼠主动脉环血管舒张作用的比较。
A comparison of the vasorelaxant effects of enoximone and dibutyryl cyclic AMP measured in rat aortic rings.
作者信息
Schweitzer D H, Koek G H, Meinders A E, van der Laarse A
机构信息
Department of Internal Medicine, University Hospital Leiden, The Netherlands.
出版信息
Res Commun Chem Pathol Pharmacol. 1990 Jun;68(3):291-7.
After preconstriction of rat aortic rings by norepinephrine (NE; 510(-5) M) or by high potassium (K+; 310(-2) M), a dose-dependent relaxation was induced by enoximone (E) in a range of 110(-5) M - 210(-4) M. The time to 50% dilatation was constant in that range, with mean values of 2.2 (NE) and 3.8 (K+) minutes. Also dibutyryl cyclic AMP (Db cAMP) in a range of 610(-5) M - 210(-3) M produced a dose-dependent relaxation. Comparison of the concentrations of E and Db cAMP producing equal extent of vasorelaxation demonstrated that inhibition of phosphodiesterase with E proved to be more effective than adding Db cAMP in equimolar dose.
在用去甲肾上腺素（NE；5×10⁻⁵ M）或高钾（K⁺；3×10⁻² M）预收缩大鼠主动脉环后，依诺昔酮（E）在1×10⁻⁵ M - 2×10⁻⁴ M范围内可诱导剂量依赖性舒张。在该范围内达到50%扩张的时间是恒定的，NE预收缩组的平均值为2.2分钟，K⁺预收缩组为3.8分钟。同样，6×10⁻⁵ M - 2×10⁻³ M范围内的二丁酰环磷酸腺苷（Db cAMP）也产生剂量依赖性舒张。对产生同等程度血管舒张的E和Db cAMP浓度进行比较表明，用E抑制磷酸二酯酶比加入等摩尔剂量的Db cAMP更有效。
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