Rosato F E, Bonn J, Shapiro M, BarBot D J, Furnary A M, Gardiner G A
Department of Radiology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
Surg Gynecol Obstet. 1990 Sep;171(3):196-200.
In two patients with malignant gastrinoma and the Zollinger-Ellison syndrome, we were able to use selective arterial stimulation with secretin as a technique to localize the lesions accurately, allowing resection. The technique of selected arterial secretin stimulation is one of measuring variations in gastrin levels in both the hepatic vein and a peripheral artery at specified times after injection of secretin into a specific artery. When the criteria for localization have been met, one can plot the presence of the gastrinoma within the blood supply of the injected artery and, using angiograms, thus accurately localize the lesion. This method promises to be a valuable additional tumor-localizing procedure, particularly when gastrinomas are extrapancreatic.
在两名患有恶性胃泌素瘤和佐林格-埃利森综合征的患者中，我们能够采用注射胰泌素后选择性动脉刺激技术来精确地定位病变，从而进行切除。选择性动脉胰泌素刺激技术是指在将胰泌素注入特定动脉后的特定时间，测量肝静脉和外周动脉中胃泌素水平的变化。当满足定位标准时，就可以确定胃泌素瘤在注入动脉供血区域内的位置，并利用血管造影精确地定位病变。这种方法有望成为一种有价值的额外肿瘤定位程序，尤其是当胃泌素瘤位于胰腺外时。
