Department of Neurology, MS Clinic, Salpêtrière Hospital, Paris, France.
Mult Scler. 2011 Dec;17(12):1520-2. doi: 10.1177/1352458511411064. Epub 2011 Jun 13.
We report the case of a young woman with multiple sclerosis who discontinued natalizumab twice and experienced a severe relapse following each natalizumab withdrawal. The first relapse was successfully treated by intravenous methylprednisolone (IVMP). In contrast the second relapse was unresponsive to IVMP. Subsequent treatment by plasma exchanges (PLEX) was followed by a dramatic neurological worsening. This case suggests that PLEX after natalizumab discontinuation may increase relapse severity.
我们报告了一例多发性硬化症年轻女性患者，她两次停用那他珠单抗，并且在每次停用后都经历了严重的复发。第一次复发通过静脉注射甲基泼尼松龙（IVMP）成功治疗。相比之下，第二次复发对 IVMP 没有反应。随后进行的血浆置换（PLEX）治疗后，神经功能恶化明显加重。该病例提示，那他珠单抗停药后行 PLEX 可能会增加复发的严重程度。
