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儿科皮肤科急症。

Pediatric dermatology emergencies.

机构信息

Division of Pediatric Dermatology, Children's Hospital of Pittsburgh, Wexford, Pennsylvania, USA.

出版信息

Curr Opin Pediatr. 2011 Aug;23(4):403-6. doi: 10.1097/MOP.0b013e3283483efd.

Abstract

PURPOSE OF REVIEW

The purpose of this review is to summarize recent advances in the diagnosis and treatment of several severe skin diseases seen in children.

RECENT FINDINGS

Several articles published recently added significantly to our understanding of drug reaction with eosinophilia and systemic symptoms (DRESS), eczema herpeticum, staphylococcal scalded skin syndrome and inherited ichthyosis. A review of 60 patients with DRESS showed 80% with hepatic involvement, 40% with renal involvement, 33% with pulmonary involvement and 50% with hematologic abnormalities. A review on eczema herpeticum describes several clinical scenarios in which it is vital to keep that diagnosis in mind. Another review on severe staphylococcal skin infections reminds us of the importance of covering for methicillin-resistant Staphylococcus aureus in all such cases until cultures and sensitivities show otherwise. The results of an international consensus conference on ichthyosis published this year will help all of us to better characterize these complicated patients. Additionally, the first case of hypothyroidism associated with a collodion baby was reported, as was the finding of an increased incidence of atypical nevi in patients with inherited ichthyosis.

SUMMARY

Although all of the conditions discussed in this article are relatively rare, it is important that they be kept on the differential diagnosis for sick infants and children with cutaneous findings, as early diagnosis and treatment of some of these conditions can be life saving.

摘要

目的综述

本文旨在总结儿童几种严重皮肤疾病的诊断和治疗的最新进展。

最新发现

最近发表的几篇文章极大地加深了我们对药物反应伴嗜酸性粒细胞增多和全身症状(DRESS)、疱疹样湿疹、葡萄球菌性烫伤样皮肤综合征和遗传性鱼鳞病的理解。对 60 例 DRESS 患者的回顾性研究显示,80%的患者有肝脏受累,40%的患者有肾脏受累,33%的患者有肺部受累,50%的患者有血液学异常。对疱疹样湿疹的综述描述了几种临床情况,在这些情况下,牢记这一诊断至关重要。另一篇关于严重葡萄球菌皮肤感染的综述提醒我们,在所有这些情况下,在培养和药敏结果出来之前,都要覆盖耐甲氧西林金黄色葡萄球菌。今年发表的国际鱼鳞病共识会议的结果将帮助我们更好地描述这些复杂的患者。此外,首例胶样婴儿相关甲状腺功能减退症的报告,以及遗传性鱼鳞病患者非典型痣发病率增加的发现。

总结

虽然本文讨论的所有疾病都相对罕见,但在出现皮肤表现的患病婴幼儿的鉴别诊断中应考虑到这些疾病,因为其中一些疾病的早期诊断和治疗可能是救命的。

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