二酰胺对红细胞中多磷酸肌醇代谢的影响。
Effect of diamide on polyphosphoinositide metabolism in red blood cells.
作者信息
Schwarzer E, Reimann B, Standera S, Jacobasch G
机构信息
Institute of Biochemistry, Humboldt University, Berlin, GDR.
出版信息
Biomed Biochim Acta. 1990;49(2-3):S255-8.
In intact red cells diamide had no strong influence on monoester phosphate group turnover of phosphatidylinositol 4,5-bisphosphate (PIP2), phosphatidylinositol 4-phosphate (PIP) and phosphatidic acid (PA) due to the potent GSH protection of these pathways in vivo. Following the complete GSH oxidation diamide impaired the turnover of PIP and PA dramatically. However that of PIP2 did not show any change. Indeed, a drastic irreversible decrease of PIP- and PA turnover was caused by a mild oxidative stress with diamide in G6PD deficient red cells.
在完整红细胞中，由于体内这些途径受到强大的谷胱甘肽（GSH）保护，二酰胺对磷脂酰肌醇4,5 - 二磷酸（PIP2）、磷脂酰肌醇4 - 磷酸（PIP）和磷脂酸（PA）的单酯磷酸基团周转没有强烈影响。在GSH完全氧化后，二酰胺显著损害了PIP和PA的周转。然而，PIP2的周转没有显示出任何变化。实际上，在G6PD缺乏的红细胞中，二酰胺引起的轻度氧化应激导致PIP和PA周转急剧且不可逆地下降。
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