Department of Surgery, Jichi Medical University Saitama Medical Center, Amanuma-cho 1-847, Omiya-ku, Saitama, Japan.
Gastric Cancer. 2011 Aug;14(3):295-9. doi: 10.1007/s10120-011-0062-0. Epub 2011 Jun 14.
We report a 75-year-old woman who suffered multiple metachronous osteosclerotic bone metastases 4 years after a distal gastrectomy for early gastric cancer (EGC). The primary tumor was a poorly differentiated adenocarcinoma, which had invaded the submucosal layer, and only one lymph node metastasis was noted. To the best of our knowledge, cases of EGC combined with metachronous osteosclerotic multiple bone and bone marrow metastases that respond to chemoradiotherapy are very rare. In this case, the multiple bone metastases were diagnosed 4 years after surgery. The patient's metastatic tumor was successfully treated using S-1, paclitaxel, and camptothecin, with subsequent irradiation. The patient survived for 24 months after the treatment, without having any major symptoms.
我们报告了一例 75 岁女性，在因早期胃癌（EGC）行远端胃大部切除术后 4 年发生多处多发性骨硬化性转移。原发肿瘤为低分化腺癌，侵犯黏膜下层，仅发现 1 枚淋巴结转移。据我们所知，EGC 合并多发性骨硬化性多发性骨及骨髓转移且对放化疗有反应的病例非常罕见。本例患者在术后 4 年诊断出多发性骨转移。该患者的转移性肿瘤经替吉奥、紫杉醇和顺铂联合治疗以及后续放疗后成功得到控制。治疗后患者存活了 24 个月，没有出现任何主要症状。
