Laboratório de Toxicologia e Essencialidade de Metais, Departamento de Análises Clínicas, Toxicológicas e Bromatológicas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café s/n, Monte Alegre, 14040-903, Ribeirão Preto, São Paulo, Brazil.
Biol Trace Elem Res. 2011 Dec;144(1-3):339-50. doi: 10.1007/s12011-011-9102-1. Epub 2011 Jun 14.
Human nails are an attractive matrix for assessing environmental exposures to toxic elements as well as the deficiency of essential elements since it is noninvasively collected and can be stored at room temperature. However, reference or baseline levels in nonexposed and healthy populations are not yet established. Then, the aims of this study were (a) to estimate background values for essential and toxic elements in nails from a healthy young population in southern Brazil and (b) to evaluate possible correlations between essential and toxic elements in nails. Furthermore, this report took part of a recent study of background values in the hair of a young population. Thus, correlations between chemical elements in nails and hair were also evaluated. Nails were collected from healthy children (n = 126), and element concentrations were determined by inductively coupled plasma mass spectrometry. This study provides new and reliable reference concentrations for toxic and essential elements in children's nails. The results can be used as reference values for epidemiological or clinical investigations based on trace elements in nails. Additionally, we also showed weak to strong correlations between Cu, Mg, Mn, Se, and Zn levels in nails and hair.
人类指甲是评估有毒元素和必需元素环境暴露以及缺乏必需元素的有吸引力的基质，因为它是非侵入性采集的，可以在室温下储存。然而，尚未确定无暴露和健康人群的参考或基线水平。因此，本研究的目的是：(a) 估计巴西南部健康年轻人群指甲中必需和有毒元素的背景值；(b) 评估指甲中必需和有毒元素之间的可能相关性。此外，本报告是最近对年轻人头发中背景值的研究的一部分。因此，还评估了指甲和头发中化学元素之间的相关性。指甲是从健康儿童中采集的（n=126），并通过电感耦合等离子体质谱法测定元素浓度。本研究为儿童指甲中的有毒和必需元素提供了新的、可靠的参考浓度。这些结果可用于基于指甲中微量元素的流行病学或临床研究的参考值。此外，我们还显示了指甲和头发中 Cu、Mg、Mn、Se 和 Zn 水平之间的弱到强相关性。
