Zhang H, D'Arpa P, Liu L F
Department of Biological Chemistry, Johns Hopkins School of Medicine, Baltimore, Maryland 21205.
Cancer Cells. 1990 Jan;2(1):23-7.
Our model proposes that topoisomerase-targeting antitumor drugs form reversible drug-enzyme-DNA complexes that collide with the DNA and RNA synthesis machineries. On collision, the complexes lose their reversibility, and generate lethal double-strand DNA breaks. Further investigations of topoisomerase action will allow this model to be refined, and may ultimately lead to the development of more effective anticancer drugs.
